Healing Stress Fractures and Broken Bones

Healing Stress Fractures and Broken Bones
Some of the new generation of non-steroidal anti-inflammatory drugs (NSAIDs) – think ibruprofin – apparently interfere with bone healing. In research led by Patrick O’Conner, Vioxx and Celebrex were found in rat tests to greatly delay or even to halt bone healing. Says O’Conner, “Ibuprofin and indomethacin delay bone healing by about one to two weeks in rats, which is equivalent to slowing it down by 25 to 50 percent in humans.” Jeremy Saklatvala of the Kennedy Institute of Rheumatology in London say more research is urgently needed, and “In the meantime, people with healing fractures should steer clear of these drugs.” (Reported in New Scientist; original research in J. Bone and Mineral Research (vol 17, p 963). (6/23/2002)

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